Improving our understanding of vascular mild cognitive impairment and vascular dementia (2 projects)

Scientific title: Characterising vascular mild cognitive impairment and vascular dementia

Type of project: PhD studentship, co-supervised by Professor Antony Bayer (Cardiff University)

What do we already know?

There is currently no way to tell which patients with mild cognitive impairment (MCI) will go on to develop dementia, and those which will not. It is important to improve early diagnosis of dementia in MCI patients as interventions are likely to be most beneficial at the earlier stages of the disease. Previous research funded by BRACE and carried out by Professor Tales and colleagues has shown that visual and attention problems can characterise Alzheimer’s disease and can be worse in people with MCI who go on to develop dementia. Also, even if individuals with MCI do not develop dementia the fact that they may have problems with their vision and attention, that may affect their quality of life, is something that needs to be investigated further and addressed. Closely related to this is the research lead by Dr Ute Leonards who is investigating how vision and attention can affect the ability of older adults to walk safely through their surroundings.

The next step is to apply these findings to improving earlier diagnosis, and to see if it is possible to differentiate between different forms of dementia at an earlier stage. Vascular disease contributes to at least 30% of cases of mild cognitive impairment or dementia, yet is very much under-investigated compared to other causes of dementia such as Alzheimer’s disease. Mild cognitive impairment associated with memory loss is often a precursor to Alzheimer’s disease, and similarly vascular mild cognitive impairment (vMCI) may be a forerunner of vascular dementia (together termed vascular cognitive impairment, VCI). Evidence suggests early changes in the brain and information processing may occur in VCI which are not picked up by standard neuropsychological testing, meaning such impairments may not be identified.

What is this project trying to find out?

The aim of this study is to advance our understanding of the features of VCI including signs, symptoms, behaviour, quality of life and changes in brain function, to determine what represents the early stages of vascular dementia. The outcome will be an improved knowledge of VCI, together with improvements for diagnosing and guiding management for those with VCI.

How will they do this?

This study will recruit healthy younger adults, cognitively healthy older adults, patients with vMCI and patients with vascular dementia. In addition to the usual clinical assessment, a battery of additional tests will be performed on iPads. Questionnaires will also be used to examine perception and understanding of the relationship between research results and real-life experiences. Together these tests will help to determine a behavioural characterisation of vMCI which will increase our understanding of some of the signs and symptoms associated with this disorder. Participants will be followed up after two and a half years to determine if the tests can help determine when vMCI may indicate an increased risk of progressing to vascular dementia.

Why is it important?

This study will enhance knowledge relating to the diagnosis of VCI, meaning people with VCI will be able to get the help they need sooner. With dementia, the chances of preventing decline are better the earlier the diagnosis occurs.

A glimpse into a new method of dementia diagnosis: pupil size as an indicator of early Alzheimer’s disease

Scientific title: Development of psychophysiological indices of early dementia

Type of project: Equipment grant

What do we already know & what is this project trying to find out?

As we age, there is a reduced pupillary response to a brief presentation of light, and this reduction is exacerbated in those with AD.  Pupillary responses are driven by the autonomic nervous system (which evidence indicates can be significantly affected in Alzheimer’s disease), and this collaborative project with Dr. Stephen Johnston – which includes the BRACE-funded purchase of cutting-edge eye-tracking technology equipment – aims to build on this research by investigating whether there are detectable differences in pupillary response to brief changes in illuminations in early forms of dementia: mild cognitive impairment (MCI) and subjective cognitive decline (SCD).

Why is it important?

This research will help ascertain whether the measurement of pupillary dynamics could form part of a non-invasive diagnostic package for predicting AD and vascular dementia from pre-symptomatic stages.

Further information

Please click here for more information about the work of Professor Andrea Tales.

Please click here for more information about the work of Professor Antony Bayer.

Please click here for more information about the work of Dr Stephen Johnston.

Andrea Tales