Our Research Getting involved in research Glossary of common dementia terms Descriptions of commonly used dementia terms: Aerobic exercise – Exercise that increases the breathing rate and ultimately raises heart and lung efficiency. Alzheimers Disease – Most common form of dementia. Caused by the abnormal build up of proteins in the brain. Over time this causes the brain to shrink in size. Clinical trial – Trial to evaluate the effectiveness and safety of medications or medical devices by monitoring their effects people. Cognitive – Things relating to the process of knowing or perceiving. Cognitive decline is when your abilities to think, perceive and reason become impaired. Dementia – An umbrella term used to describe a range of progressive neurological disorders; conditions affecting the brain and nervous system. Depression – A mood disorder that negatively affects how someone is feeling. Typically marked by sadness, inactivity and difficulty in thinking and concentration. Many of the symptoms of dementia can also be caused by depression. Diagnosis – The act of determining the nature and cause of a disease or injury through evaluation of patient history, examination, and review of laboratory data. Endocrine gland – A gland responsible for hormone secretion. Frontotemporal dementia – Least common form of dementia. Caused by the death of nerve cells in the frontal and/or temporal lobes of the brain. Symptoms include changes in personality and behaviour as well as difficulty controlling emotions. Gene – A sequence of DNA that may be further processed to produce a protein with a specific function. Genetic Test – A genetic test allows the identification certain genes that may increase the risk of Alzheimers disease. Grant Application / Grant – A submission, typically by a researcher, to a research council to ask for funds to complete pre-planned research. Haemoglobin - An iron containing protein found in the blood. This protein is responsible for carrying oxygen from the lungs to vital organs. Hormones – A chemical produced by living cells that circulated in bodily fluids and produces an often stimulatory effect on the body. In vitro studies – Studies which are conducted outside the living organism. In vivo – Studies which are conducted inside the living organism. Lewy body dementia – Lewy body dementia shares some symptoms of both Alzheimers and Parkinson’s disease. Caused by protein build up in nerve cells. Lumbar Puncture – A medical procedure that may indicate Alzheimers disease. A sample of cerebrospinal fluid can be taken from the lower back. The proteins in this fluid can indicate whether a patient has Alzheimers disease. Mild cognitive impairment – A stage between the expected cognitive decline of aging and the more serious decline of dementia. This can involve, but is not limited to, memory and language problems. Although typically associated with dementia, mild cognitive impairment (MCI) can also be caused by other conditions such as anxiety and depression. Mixed dementia – Where more than one type of dementia is present in a patient. MRI Scan – MRI stands for magnetic resonance imaging. This is a non-invasive medical imaging technique used to create an image of the brain which can help confirm a diagnosis of dementia. Neurone – A nerve cell which makes up a part of the nervous system of the brain. Parkinsons Disease – A long-term degenerative disorder of the central nervous system that mainly affects the motor system. Peer Review – The process by which proposed research is reviewed by independent researchers (known as referees) to evaluate the importance of the research. PhD Studentship – PhD stands for Doctor of Philosophy. A PhD is a postgraduate doctoral degree, awarded to students who complete a thesis offering a significant new contribution to knowledge in their subject. Pilot Project – A small scale preliminary study designed to evaluate usefulness, length, cost and potential adverse effects of a study before a full-scale research project takes place. Post-Doctoral Fellowship – A fellowship awarded for a researcher to conduct research after the completion of their doctoral studies. Psychiatric Evaluation – A way of assessing an individual’s behaviour to determine whether depression or any other mental health condition may be contributing to an individual’s condition. Repurposing drugs – The discovery of new uses for ‘old’ clinically approved drugs. Research councils – A funding body which engages in the support of research in different disciplines. Scientific Advisory Committee – An independent committee of scientists which recommends to trustees which scientific applications should be supported. Symptom – An indication of a disorder or a disease. Therapeutic target – The biological target which is affected by a drug. This effect causes the biological response of the drug (eg. Pain relief for ibuprofen). Thyroid - The thyroid gland, or simply the thyroid, is an endocrine gland located in the neck. Trustee - Trustees have overall control of the charity and are responsible for making sure it’s doing what it was set up to do. Vascular – Relating to the blood vessels in the brain. Vascular dementia – Second most common form of dementia. Caused by damaged blood vessels in the brain. Symptoms vary but may include memory loss and language difficulties.